Dilemma of being a neuron

If you were a neuron, you would need fast excitatory transmission and fast synaptic inhibition. The first - fast excitatory transmission - is mediated by AMPA and the second - inhibition - is mediated by GABA.

Since the inhibition by GABA is mostly in the synapses and the excitation is in the body of the neuron, you will have to package them and transport them to two different destinations. Or you could just send them generally to the plasma membrane and let them settle down where they are needed. 

What will you do?

If neurons were people, the answer would have been easy. But neurons don't talk. So you have to quiz them with scientific procedures and protocols. A recent paper in PNAS, Differential vesicular sorting of AMPA and GABAA receptors, does just that. Using total internal reflection fluorescence microscopy  in combination with immunocytochemistry, electrophysiology, and electron microscopy methods they confirm what method neurons use to distribute the receptors in different parts of the cell membrane.

Here is a short video from the report:

It appears that neurons are rather sensible. They package the goods into vesicles in golgi bodies and transport them separately to different destinations as per the need.